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One could argue that the higher predisposition to autoimmune disease in women (Cooper and Stroehla, 2003) prompted the sister to react to the subtle white matter damage induced by this mutation in an inflammatory MS-like manner, whereas the brother proceeded along a degenerative path in the absence of the autoimmune overlay

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10.1186/1475-2891-12-142 243 LeeC.RaffaghelloL.BrandhorstS.SafdieF